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Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection

Deeksha Munnur, Qi Wen Teo, Denzel Eggermont, Horace H.Y. Lee, Fabien Théry, Julian Ho, Sophie Wilhelmina van Leur, Wilson W. Ng, Lewis Siu, Antje Beling, Hidde L. Ploegh, Adán Pinto-Fernández, Andreas Damianou, Benedikt M. Kessler, Francis Impens, Chris Ka Pun Mok, Sumana Sanyal

2021Nature Immunology147 citationsDOIOpen Access PDF

Topics & Concepts

MacrophageImmune systemBiologyVirologyImmunologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)MedicineGeneticsInfectious disease (medical specialty)DiseaseIn vitroPathologyCOVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Researchinterferon and immune responses
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection | Litcius