NHPI/O<sub>2</sub>‐Mediated Electrochemical Intermolecular Cyclization/Dehydrogenation for the Construction of Polycyclic Quinazolinones
Lei Liu, Zhenhui Xu, Jie Lin, Zhensheng Zhang, Yongzhen Wu, Pengtao Yang, Yunfei Hang, Dingguo Song, Weihui Zhong, Fei Ling
Abstract
Abstract Herein, an eco‐friendly and atom‐economical electrochemical methodology with isatins and 1,2,3,4‐tetrahydroisoquinolines through NHPI/O 2 ‐mediated intermolecular oxidation/annulation is disclosed, leading to a variety of polycyclic quinazolinones in 46–82% yields. This oxidative cyclization proceeded in transition metal‐ and strong oxidant‐free conditions and generated H 2 and CO 2 as byproducts. Additionally, late‐stage functionalization and broad substrate scope demonstrated the synthetic usefulness of this protocol.
Topics & Concepts
ChemistryAnnulationDehydrogenationIntermolecular forceCombinatorial chemistryElectrochemistrySubstrate (aquarium)Transition metalOrganic chemistryMoleculeCatalysisElectrodePhysical chemistryGeologyOceanographyQuinazolinone synthesis and applicationsCatalytic C–H Functionalization MethodsElectrocatalysts for Energy Conversion