A mechanism-inspired UDP- <i>N</i> -acetylglucosamine pyrophosphorylase inhibitor
Olawale G. Raimi, Ramón Hurtado‐Guerrero, Vladimir S. Borodkin, Andrew T. Ferenbach, Michael D. Urbaniak, Michael A. J. Ferguson, Daan M. F. van Aalten
Abstract
UTP) was designed and synthesized and was shown to be a micromolar inhibitor of the enzyme. The mechanistic insights and inhibitor described here will facilitate future studies towards the discovery of small molecule inhibitors of this currently unexploited potential antifungal drug target.
Topics & Concepts
N-AcetylglucosamineUridine diphosphateAcetylglucosamineNucleotideBiosynthesisChemistryGlycosyltransferaseBiochemistryUridineNucleotide sugarSugarMechanism (biology)Cell biologyEnzymeStereochemistryBiologyGenePhilosophyRNAEpistemologyCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchBiochemical and Molecular Research