Nrf2 silencing amplifies DNA photooxidative damage to activate the STING pathway for synergistic tumor immunotherapy
Shengjie Sun, Mian Yu, Yu Liu, Wenxin Huang, Meishu Zhu, Yanan Fu, Lingchen Yan, Qiang Wang, Xiaoyuan Ji, J. Zhao, Meiying Wu
Topics & Concepts
Oxidative stressStimulator of interferon genesDNA damageImmune systemReactive oxygen speciesImmunogenicityTumor microenvironmentCancer researchCell biologyImmunogenic cell deathGlutathioneBiologyImmunotherapyImmunologyInnate immune systemDNABiochemistryEnzymeNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer, Hypoxia, and Metabolism