Selective cellular probes for mammalian thioredoxin reductase TrxR1: Rational design of RX1, a modular 1,2-thiaselenane redox probe
Lukas Zeisel, Jan G. Felber, Karoline Scholzen, Lena Poczka, Dorian M. Cheff, Martin S. Maier, Qing Cheng, Min Shen, Matthew D. Hall, Elias S.J. Arnér, Julia Thorn‐Seshold, Oliver Thorn‐Seshold
Topics & Concepts
Thioredoxin reductaseSelenoproteinThioredoxinGlutaredoxinDrug discoveryChemistryBiochemistryOxidoreductaseRibonucleotide reductaseReductaseCell biologyDrug developmentEnzymeComputational biologyBiologyDrugPharmacologyGeneGlutathione peroxidaseGlutathioneProtein subunitRedox biology and oxidative stressSulfur Compounds in BiologyOrganoselenium and organotellurium chemistry