Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor Formation
Derek K. Smith, Lance Kates, Steffen Durinck, Nisha Patel, Eric Stawiski, Noelyn M. Kljavin, Oded Foreman, Bence Sipos, Mark J. Solloway, Bernard B. Allan, Andrew S. Peterson
Abstract
loss-of-function variants and find prominent tumor-cell-associated expression of the SLC38A5 paralog SLC7A8 as well as markers of active mTOR signaling. Thus, progenitor cells arise from adult alpha cells in response to metabolic signals and, when inductive signals are chronically present, drive tumor initiation.
Topics & Concepts
Alpha cellBiologyProgenitor cellGlucagon receptorGlucagonCancer researchGermlineEndocrinologyCell biologyCellEmbryonic stem cellReceptorPI3K/AKT/mTOR pathwayAlpha (finance)PopulationInternal medicineSignal transductionHormoneStem cellBeta cellInsulinGeneticsGeneMedicineNursingIsletPatient satisfactionConstruct validityEnvironmental healthNeuroendocrine Tumor Research AdvancesPancreatic function and diabetesLung Cancer Research Studies