Targeted modulation of intestinal epithelial regeneration and immune response in ulcerative colitis using dual-targeting bilirubin nanoparticles
Zewei Zhuo, Kehang Guo, Yujun Luo, Qi Yang, Huihuan Wu, Ruijie Zeng, Rui Jiang, Jingwei Li, Rui Wei, Qizhou Lian, Weihong Sha, Yuliang Feng, Hao Chen
Abstract
Overall, our work provides an efficient colon targeted drug delivery system to potentiate the treatment of ulcerative colitis via modulating intestinal epithelium regeneration and immune response in ulcerative colitis.
Topics & Concepts
Ulcerative colitisImmune systemImmune modulationRegeneration (biology)BilirubinMedicineCancer researchImmunologyInternal medicineBiologyCell biologyDiseaseHeme Oxygenase-1 and Carbon MonoxideLiver Disease Diagnosis and TreatmentOrgan Transplantation Techniques and Outcomes