Host fibrinogen drives antimicrobial function in <i>Staphylococcus aureus</i> peritonitis through bacterial-mediated prothrombin activation
Joni M. Prasad, Oscar Negrón, Xinli Du, Eric S. Mullins, Joseph S. Palumbo, Jessica M. Gilbertie, Magnus Höök, Steven P. Grover, Rafał Pawliński, Nigel Mackman, Jay L. Degen, Matthew J. Flick
Abstract
, but clearance of these same microbes in WT mice was restored if active thrombin was administered to the peritoneal cavity. These studies establish that the thrombin/fibrinogen axis is fundamental to host antimicrobial defense, offer a possible explanation for the clinical observation that coagulase-negative staphylococci are a highly prominent infectious agent in peritonitis, and suggest caution against anticoagulants in individuals susceptible to peritoneal infections.
Topics & Concepts
FibrinogenStaphylococcus aureusMicrobiologyFibrinThrombinAntimicrobialPeritonitisPeritoneal cavityStaphylococcal infectionsImmunologyBiologyMedicinePlateletBacteriaInternal medicineBiochemistrySurgeryGeneticsAntimicrobial Resistance in StaphylococcusStreptococcal Infections and TreatmentsClostridium difficile and Clostridium perfringens research