Synthesis and short DNA<i>in situ</i>loading and delivery of 4 nm-aperture flexible organic frameworks
Zekun Wang, Jia-Le Lin, Yunchang Zhang, Chenwu Yang, Ya-Kun Zhao, Zhengwei Leng, Hui Wang, Dan‐Wei Zhang, Jiang Zhu, Zhan‐Ting Li
Abstract
Water-soluble hydrazone-connected 3D flexible organic frameworks have been revealed to<italic>in situ</italic>load and deliver short DNA into normal and cancer cells.
Topics & Concepts
In situMaterials scienceAperture (computer memory)NanotechnologyChemical engineeringChemistryOrganic chemistryMechanical engineeringEngineeringAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryDendrimers and Hyperbranched Polymers