A comparative analysis of 3D printed scaffolds consisting of poly(lactic-<i>co</i>-glycolic) acid and different bioactive mineral fillers: aspects of degradation and cytocompatibility
Tilman Ahlfeld, Anja Lode, Anna-Maria Placht, Tatjana Fecht, Tobias Wolfram, Stefanie Grom, Andreas Hoess, Corina Vater, Christian Bräuer, Sascha Heinemann, Günter Lauer, Frank Reinauer, Michael Gelinsky
Abstract
. Cell culture experiments with the human osteosarcoma cell line SAOS-2 and human dental pulp stem cells (hDPSC) indicated the high cytocompatibility of the composites: For all material groups cell spreading and complete colonization of the scaffolds over the culture period of 14 days as well as an increase of the specific alkaline phosphatase activity, typical for osteogenic differentiation, were observed.
Topics & Concepts
PLGABiomaterialGlycolic acidDegradation (telecommunications)ChemistryLactic acidBiomedical engineeringIn vitroMaterials scienceComputer scienceBiochemistryMedicineOrganic chemistryBiologyBacteriaGeneticsTelecommunicationsBone Tissue Engineering Materialsbiodegradable polymer synthesis and propertiesGraphene and Nanomaterials Applications