Adaptivity and dynamics in type III secretion systems
Bailey Milne‐Davies, Stephan Wimmi, Andreas Diepold
Abstract
The type III secretion system is the common core of two bacterial molecular machines: the flagellum and the injectisome. The flagellum is the most widely distributed prokaryotic locomotion device, whereas the injectisome is a syringe-like apparatus for inter-kingdom protein translocation, which is essential for virulence in important human pathogens. The successful concept of the type III secretion system has been modified for different bacterial needs. It can be adapted to changing conditions, and was found to be a dynamic complex constantly exchanging components. In this review, we highlight the flexibility, adaptivity, and dynamic nature of the type III secretion system.
Topics & Concepts
FlagellumBiologySecretionFlexibility (engineering)Type three secretion systemVirulenceComputational biologyType (biology)Cell biologyMicrobiologyBacteriaGeneticsBiochemistryEcologyGeneMathematicsStatisticsBacterial Genetics and BiotechnologyVibrio bacteria research studiesBacteriophages and microbial interactions