Spironolactone hyaluronic acid enriched cerosomes (HAECs) for topical management of hirsutism: <i>in silico</i> studies, statistical optimization, <i>ex vivo,</i> and <i>in vivo</i> studies
Rofida Albash, Abdurrahman M. Fahmy, Mohammed I.A. Hamed, Khaled M. Darwish, Rania Moataz El-Dahmy
Abstract
studies concluded better skin deposition and accumulation of SP from OHAEC. The histopathological study demonstrated the safety of OHAEC for topical application. Therefore, OHAEC could be considered as effective system for topical application of SP to manage hirsutism, with prolonged action, coupled with minimized side effects.
Topics & Concepts
Ex vivoIn vivoHyaluronic acidChemistrySpironolactonePharmacologyIn vitroBiochemistryBiologyEndocrinologyGeneticsBiotechnologyAldosteroneDermatology and Skin DiseasesAdvancements in Transdermal Drug DeliveryNail Diseases and Treatments