Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates
Ahmed M. Moustafa, Colleen Bianco, Lidiya Denu, Azad Ahmed, Susan Coffin, Brandy Neide, J.K. Everett, Shantan Reddy, Emilie Rabut, Jasmine Deseignora, Michael D. Feldman, Kyle G. Rodino, Frederic D. Bushman, Rebecca M. Harris, Josh Chang Mell, Paul J. Planet
Abstract
We report the genome of a B.1.1.7+E484K severe acute respiratory syndrome coronavirus 2 from Southeastern Pennsylvania and compare it with all high-coverage B.1.1.7+E484K genomes (n = 235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the United States and the possibility of at least 59 independent acquisitions of the E484K mutation.
Topics & Concepts
CladeGenomeCoronavirus disease 2019 (COVID-19)MedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakMutationVirologyCoronavirusGeneticsComputational biologyBiologyGenePhylogeneticsOutbreakInternal medicineDiseaseInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesViral gastroenteritis research and epidemiology