Design of antimicrobial peptides containing non-proteinogenic amino acids using multi-objective Bayesian optimisation
Yuki Murakami, Shoichi Ishida, Yosuke Demizu, Kei Terayama
Abstract
MODAN is a multi-objective Bayesian framework for automated design of antimicrobial peptides containing various non-proteinogenic amino acids and side-chain stapling.
Topics & Concepts
Amino acidAntimicrobialAntimicrobial peptidesChemistryBayesian probabilityBiochemistryMathematicsComputer scienceArtificial intelligenceOrganic chemistryAntimicrobial Peptides and ActivitiesChemical Synthesis and Analysisvaccines and immunoinformatics approaches