Electrochemical Nickel‐Catalyzed Selective Inter‐ and Intramolecular Arylations of Cysteine‐Containing Peptides**
Linhua Shen, Olivier Monasson, Elisa Peroni, Franck Le Bideau, Samir Messaoudi
Abstract
Here we report a simple electrochemical route towards the synthesis of S-arylated peptides by a site selective coupling of peptides with aryl halides under base free conditions. This approach demonstrates the power of electrochemistry to access both highly complex peptide conjugates and cyclic peptides.
Topics & Concepts
Intramolecular forceNickelElectrochemistryCatalysisCysteineChemistryCombinatorial chemistryStereochemistryOrganic chemistryEnzymeElectrodePhysical chemistryRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods