Network pharmacology and experimental evidence: ERK/CREB/BDNF signaling pathway is involved in the antidepressive roles of Kaiyu Zhishen decoction
Ying Chen, Xiangxu Chen, Jialin Zhang, Xuejun Zhang, Dan Wang, Na Lü, Changsong Wang, Yingying Yue, Yonggui Yuan
Topics & Concepts
MAPK/ERK pathwayPharmacologyAntidepressantCREBMedicineMajor depressive disorderFluoxetineSignal transductionNeuroscienceBiologyInternal medicineHippocampusReceptorTranscription factorCell biologyBiochemistrySerotoninAmygdalaGeneTryptophan and brain disordersTreatment of Major DepressionNeurotransmitter Receptor Influence on Behavior