Advanced design and development of nanoparticle/microparticle dual-drug combination lactose carrier-free dry powder inhalation aerosols
Priya Muralidharan, Evan Mallory, Monica Malapit, Hanna Phan, Julie G. Ledford, Don Hayes, Heidi M. Mansour
Abstract
: this study has successfully produced a lactose-free dry powder formulation containing fluticasone propionate and salmeterol xinafoate with mannitol as excipient engineered as inhalable DPI nanoparticles/microparticles by advanced spray drying. Further, co-spray drying with mannitol and using Handihaler® device can generate higher fine particle mass of fluticasone/salmeterol. Mannitol, a mucolytic agent and aerosol performance enhancer, is a suitable excipient that can enhance aerosol dispersion of DPIs.
Topics & Concepts
Dry-powder inhalerLactoseFluticasone propionateSpray dryingSalmeterolParticle sizeMicroparticleNanoparticleMaterials scienceInhalerChromatographyChemistryInhalationNanotechnologyChemical engineeringMedicineAsthmaFood scienceAnesthesiaInternal medicineEngineeringPhysical chemistryInhalation and Respiratory Drug DeliveryAsthma and respiratory diseasesRespiratory and Cough-Related Research