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Tailored horseshoe-shaped nicotinonitrile scaffold as dual promising c-Met and Pim-1 inhibitors: Design, synthesis, SAR and in silico study

Samy Mohamady, Ahmed Khalil, Bassem H. Naguib, Mohamed S. Nafie, Haytham O. Tawfik, Moataz A. Shaldam

2023Bioorganic Chemistry13 citationsDOI

Topics & Concepts

ChemistryKinaseMTT assayCytotoxicityCell cultureIC50In silicoApoptosisBiochemistryIn vitroStereochemistryBiologyGeneGeneticsCancer Mechanisms and TherapySynthesis and biological activitySynthesis and bioactivity of alkaloids
Tailored horseshoe-shaped nicotinonitrile scaffold as dual promising c-Met and Pim-1 inhibitors: Design, synthesis, SAR and in silico study | Litcius