One-Step Synthesis of Benzophosphole Derivatives from Arylalkynes by Phosphenium-Dication-Mediated Sequential C–P/C–C Bond Forming Reaction
Kazutoshi Nishimura, Shibo Xu, Yuji Nishii, Koji Hirano
Abstract
A metal-free, phosphenium-dication-mediated sequential C-P and C-C bond forming reaction has been developed. This protocol can provide concise access to the (di)benzophosphole derivatives in one synthetic operation from the readily available and simple arylalkynes and phosphinic acids. Application to the multiple cyclization reaction and the fully intermolecular three-component-coupling-type reaction are also described.
Topics & Concepts
DicationChemistryIntermolecular forceCombinatorial chemistryTriple bondComponent (thermodynamics)StereochemistryDouble bondMoleculeOrganic chemistryPhysicsThermodynamicsSynthesis and characterization of novel inorganic/organometallic compoundsCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods