<i>Fgfr3</i> mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling
Xianding Sun, Ruobin Zhang, Hangang Chen, Xiaolan Du, Daiwen Chen, Junlan Huang, Mi Liu, Meng Xu, Fengtao Luo, Min Jin, Nan Su, Huabing Qi, Jing Yang, Qiaoyan Tan, Dali Zhang, Zhenhong Ni, Sen Liang, Bin Zhang, Di Chen, Xin Zhang, Lingfei Luo, Lin Chen, Yangli Xie
Abstract
in skeleton development. Our findings provide evidence that modulation of Wnt/β-catenin activity could be a potential therapy for CATSHL syndrome and related skeleton diseases.
Topics & Concepts
ZebrafishBiologyWnt signaling pathwayFibroblast growth factorCell biologyEndochondral ossificationCraniofacialPathologyAnatomyCartilageSignal transductionMedicineGeneticsReceptorGeneFibroblast Growth Factor ResearchGenetic Syndromes and ImprintingConnective tissue disorders research