<i>In Vitro</i> Susceptibility of Treponema pallidum subsp. <i>pallidum</i> to Doxycycline
Diane G. Edmondson, Gary P. Wormser, Steven J. Norris
Abstract
Doxycycline is regarded as an effective therapy for early syphilis, and there is increasing interest in using doxycycline for prophylaxis of this infection. However, the MIC of doxycycline for Treponema pallidum subsp. pallidum has not been reported previously. In this study, an in vitro culture system was utilized to determine that the MIC of doxycycline is 0.06 to 0.10 μg/ml for four strains of T. pallidum subsp.
Topics & Concepts
DoxycyclineTreponemaSyphilisMicrobiologyBiologyIn vitroVirologyAntibioticsGeneticsHuman immunodeficiency virus (HIV)Syphilis Diagnosis and TreatmentReproductive tract infections researchFemale Genital Mutilation/Cutting Issues