GC‐MS Analysis, Antioxidant and Antifungal Studies of Different Extracts of <i>Chaetomium globosum</i> Isolated from <i>Urginea indica</i>
Shailja Kumari, Swati Kumari, Chandrika Attri, Ruchi Sharma, Sourabh Kulshreshtha, Taoufiq Benali, Abdelhakim Bouyahya, Eda Sönmez Gürer, Javad Sharifi‐Rad
Abstract
To discover new natural resources with biological effects, the chemical investigation of antioxidant and antimicrobial activities of extract’s Chaetomium globosum isolated from roots of Urginea indica . Gas chromatography‐mass spectrometry (GC‐MS) analysis demonstrated the presence of the major chemical constituents present in the methanol extract (1,3‐oxathiolane, 1,3‐cyclopentadiene, 5‐(1‐methylethylidene), 5,9‐hexadecadienoic acid, methyl ester, decane), chloroform extract (acetic acid, diethoxy‐, ethyl ester, 2,2‐bis(ethylsulfonyl)propane, 3‐methyl‐2‐(2‐oxopropyl) furan), and hexane extract (3‐hexanone, 4,4‐dimethyl, decane,2,6‐dimethyldecane, decane, 2,4,6‐trimethyl, decane, 2,4,6‐trimethyl, 1‐butanesulfinamide, 1,1,2,2,3,3,4,4,4‐nonafluoro‐N‐methyl, decane). The total compound identified (56.2%) in chloroform extract, (54.72%) in hexane extract, and (65%) in methanol extract. The antioxidant effects were performed using diphenylpicrylhydrazyl radical (DPPH). The results showed that the methanol extract showed significantly the highest anti‐DPPH with an IC 50 value of 37.61 ± 1.37 μ g/mL, followed by chloroform and hexane extracts with IC 50 values of 40.82 ± 3.60 and 45.20 ± 2.54 μ g/mL, respectively. The antifungal activity of extracts was evaluated against pathogens fungi including Fusarium oxysporum , Rosellinia necatrix , Cladosporium xanthochromaticum , and Sclerotinia sclerotiorum . Methanolic and chloroform extracts showed maximum inhibition against all test pathogens, while hexane extract showed minimum inhibition.