A series of 4-thiomorpholinophenyl-thiosemicarbazones as cholinesterase inhibitors with anti-neuroblastoma effects
Hina Aftab, Furkan Çakır, Gurbet Çelik Turgut, Nastaran Sadeghian, Rima D. Alharthy, Parham Taslımı, Alaattin Şen, Magdi E. A. Zaki, Sobhi M. Gomha, Javid Hussain, Zahid Shafiq, Halil Şenol
Topics & Concepts
ButyrylcholinesteraseChemistryAcetylcholinesteraseADMECholinesteraseCytotoxicityStereochemistryDocking (animal)AchéEnzymeStructure–activity relationshipPharmacologySelectivityCombinatorial chemistryLead compoundMolecular modelvan der Waals forceIC50TacrineBiochemistryIn vitroLipophilicityBiophysicsEnzyme inhibitorCholinesterase and Neurodegenerative DiseasesEnzyme function and inhibitionMetal complexes synthesis and properties