Cell-imprinted substrates: in search of nanotopographical fingerprints that guide stem cell differentiation
Khorshid Kamguyan, Saeed Zajforoushan Moghaddam, Abolfazl Nazbar, Seyed Mohammad Amin Haramshahi, Shiva Taheri, Shahin Bonakdar, Esben Thormann
Abstract
Cell-imprinted substrates direct stem cell differentiation into various lineages, suggesting the idea of lineage-specific nanotopography. We herein examined the surface topography of five different imprinted cell patterns using AFM imaging and statistical analysis of amplitude, spatial, and hybrid roughness parameters. The results suggest that different cell imprints possess distinguished nanotopographical features.
Topics & Concepts
Stem cellCellBiologyCell biologyGeneticsCancer Cells and Metastasis3D Printing in Biomedical ResearchMicrofluidic and Bio-sensing Technologies