Iron catalyzed tandem ring opening/1,6-conjugate addition of cyclopropanols with <i>p</i>-quinone methides: new access to γ,γ-diaryl ketones
Sachin R. Shirsath, Sagar M. Chandgude, M. Muthukrishnan
Abstract
-quinone methides leading to γ,γ-diaryl ketones has been described. This catalytic protocol provides a novel and efficient method to access γ,γ-diaryl ketone derivatives in good to excellent yields with high functional group tolerance. Importantly, γ,γ-diaryl ketone can be further functionalized to give a versatile set of useful products.
Topics & Concepts
ConjugateTandemChemistryCatalysisRing (chemistry)KetoneCombinatorial chemistryFunctional groupMedicinal chemistryOrganic chemistryMaterials scienceMathematicsComposite materialMathematical analysisPolymerSynthesis of Indole DerivativesSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods