Network Physiology in Aging and Frailty: The Grand Challenge of Physiological Reserve in Older Adults
Román Romero‐Ortuño, Nicolás Martínez‐Velilla, Richard Sutton, Andrea Ungar, Artur Fedorowski, Rose Galvin, Olga Theou, Andrew Davies, Richard B. Reilly, Jurgen A.H.R. Claassen, Aine Marie Kelly, Plamen Ch. Ivanov
Abstract
In this Specialty Grand Challenge, we outline our vision of the current challenges in the field of Network Physiology as applied to aging and frailty. An expected development in this field for the 21st century is the modelling of the widely used (but still poorly understood) concept of ‘physiological reserve’ in relation to the wide heterogeneity in health status that exists between older adults of the same chronological age.
Topics & Concepts
GerontologySpecialtyMedicinePsychiatryHeart Rate Variability and Autonomic ControlCardiovascular Syncope and Autonomic DisordersFunctional Brain Connectivity Studies