Photoinduced regioselective difluorination of secondary inert C(sp<sup>3</sup>)–H bonds in sulfonamides <i>via</i> 1,5-hydrogen-atom transfer
Zhi Chen, Wenkai Zhu, Chaodong Wang, Ning Xu, Qianxi Jin, Xule Huang, Shengjie Song, Jianjun Li
Abstract
Difluorinated compounds are important structural motifs in organic synthesis and medicinal chemistry because fluoride can modulate the properties of various molecules.
Topics & Concepts
ChemistryRegioselectivityMoleculeHydrogen atomHydrogen bondInertPhotochemistryFluorideMedicinal chemistryCombinatorial chemistryOrganic chemistryInorganic chemistryGroup (periodic table)CatalysisFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques