Breaking the unbreakable: A paediatric case of dolutegravir resistance from KwaZulu-Natal
Sibongiseni Malinga, Aabida Khan, Moherndran Archary
Abstract
We report a case of dolutegravir resistance in KwaZulu-Natal in a 13-year-old male two years after starting dolutegravir. Resistance most likely developed due to poor adherence as a result of psychosocial issues. This case highlights the importance of the role of the family unit in impacting adherence and close monitoring of treatment-experienced patients with virologic failure following switching to dolutegravir-based regimens.
Topics & Concepts
DolutegravirMedicinePsychosocialDrug resistancePediatricsHuman immunodeficiency virus (HIV)VirologyAntiretroviral therapyPsychiatryViral loadGeneticsBiologyHIV/AIDS drug development and treatmentHIV/AIDS Research and InterventionsAcute Lymphoblastic Leukemia research