Plasma exosomal <i>miR-375-3p</i> regulates mitochondria-dependent keratinocyte apoptosis by targeting XIAP in severe drug-induced skin reactions
Chen Zhang, Zhenlai Zhu, Jixin Gao, Luting Yang, Erle Dang, Hui Fang, Shuai Shao, Shaolong Zhang, Chunying Xiao, Yuan Xu, Wei Li, Riichiro Abe, Hongjiang Qiao, Gang Wang, Meng Fu
Abstract
Circulating exosomal miR-375-3p promotes keratinocyte apoptosis via XIAP repression in Stevens-Johnson syndrome and toxic epidermal necrolysis.
Topics & Concepts
XIAPKeratinocyteMicrovesiclesApoptosisExosomeInhibitor of apoptosisCell biologyCancer researchChemistrymicroRNACD63In vitroImmunologyBiologyProgrammed cell deathCaspaseBiochemistryGeneExtracellular vesicles in diseaseDrug-Induced Adverse ReactionsAdvancements in Transdermal Drug Delivery