Incidence of Amyloid-Related Imaging Abnormalities in Phase III Clinical Trials of Anti-Amyloid-β Immunotherapy
So Yeong Jeong, Chong Hyun Suh, Jae‐Sung Lim, Woo Hyun Shim, Hwon Heo, Yangsean Choi, Ho Sung Kim, Sang Joon Kim, Jae‐Hong Lee
Abstract
Amyloid-related imaging abnormalities (ARIA) are key safety considerations in anti-amyloid-β (Aβ) immunotherapy. ARIA can be categorized into 2 types: ARIA characterized by edema and effusion (ARIA-E) or microhemorrhages and superficial siderosis (ARIA-H). In this study, we assessed the incidence of ARIA in phase 3 randomized controlled trials (RCTs) of anti-Aβ immunotherapy and compared the incidence among different agents and APOE ε4 carrier status.
Topics & Concepts
Incidence (geometry)Amyloid (mycology)ImmunotherapyMedicineClinical trialAmyloid βPathologyImmunologyDiseaseImmune systemOpticsPhysicsAlzheimer's disease research and treatmentsAmyloidosis: Diagnosis, Treatment, OutcomesLanthanide and Transition Metal Complexes