Supplementation with <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> MH-022 for remission of motor impairments in a 6-OHDA-induced Parkinson's disease rat model by reducing inflammation, reshaping the gut microbiome, and fostering specific microbial taxa
Shu‐Ping Tsao, Tu‐Hsueh Yeh, Ya‐Tin Lin, Chun Pan, Yuan Kun Lee, Chieh‐Hsi Wu, Hui-Yu Huang
Abstract
MH-022 in modulating diverse aspects of PD, particularly highlighting its role in reducing inflammation, restoring mitochondrial function, enhancing antioxidant capacity, and reshaping the gut microbiota. This multifaceted approach underscores the probiotic's potential in reducing neuroinflammation and protecting dopaminergic neurons, thus offering a promising avenue for PD treatment.
Topics & Concepts
Bifidobacterium animalisParkinson's diseaseInflammationDiseaseMedicineRat modelInternal medicineBifidobacteriumEndocrinologyBiologyBacteriaLactobacillusGeneticsGABA and Rice ResearchSirtuins and Resveratrol in MedicineParkinson's Disease Mechanisms and Treatments