Single-cell RNA sequencing identifies critical transcription factors of tumor cell invasion induced by hypoxia microenvironment in glioblastoma
Yanru Zhang, Bo Zhang, Chengqian Lv, Nan Zhang, Kaiyuan Xing, Zixuan Wang, Rongkai Lv, Mingchen Yu, Chaohan Xu, Yihan Wang
Abstract
Our work revealed the critical regulators in hypoxic subpopulation with high invasive potential in GBM, which may have practical implications for clinical targeted-hypoxia cancer drug therapy.
Topics & Concepts
Tumor microenvironmentHypoxia (environmental)Cancer researchBiologyTumor hypoxiaTranscriptomeCellCancer cellBrain tumorCancerGeneMedicineGene expressionPathologyTumor cellsChemistryInternal medicineOrganic chemistryGeneticsBiochemistryOxygenRadiation therapySingle-cell and spatial transcriptomicsCancer, Hypoxia, and MetabolismImmune cells in cancer