S1PR2/RhoA/ROCK1 pathway promotes inflammatory bowel disease by inducing intestinal vascular endothelial barrier damage and M1 macrophage polarization
Xuewen Wang, Shuhua Chen, Hong Xiang, Xiaoyan Wang, Jie Xiao, Shaoli Zhao, Zhihao Shu, Jie Ouyang, Ziwei Liang, Minzi Deng, Xuejie Chen, Jing Zhang, Huiqin Liu, Qisheng Quan, Peng Gao, Jianing Fan, Alex F. Chen, Hongwei Lü
Topics & Concepts
RHOAMacrophage polarizationCell biologyROCK1Inflammatory bowel diseaseS1PR1Barrier functionCancer researchBiologySignal transductionMacrophageImmunologyChemistryMedicineVascular endothelial growth factor AIn vitroBiochemistryInternal medicineVascular endothelial growth factorVEGF receptorsDiseaseSphingolipid Metabolism and SignalingImmune cells in cancerInflammasome and immune disorders