<i>Staphylococcus aureus</i> Infection Initiates Hypoxia-Mediated Transforming Growth Factor-β1 Upregulation to Trigger Osteomyelitis
Wei Zhang, Yiwei Lin, Yang Zong, Xin Ma, Chaolai Jiang, Haojie Shan, Wenyang Xia, Lifu Yin, Nan Wang, Lihui Zhou, Zubin Zhou, Xiaowei Yu
Abstract
The pathogenesis of osteomyelitis induced by Staphylococcus aureus remains unclear. To develop therapeutic approaches for osteomyelitis, it is important to understand the molecular mechanisms of its pathogenesis. Our results suggests that hypoxia/HIF-1α/TGF-β1 signaling is involved in osteomyelitis pathogenesis. Thus, these findings highlight the potential of this signaling components as therapeutic targets for the treatment of osteomyelitis.
Topics & Concepts
PathogenesisStaphylococcus aureusOsteomyelitisHypoxia (environmental)RUNX2Downregulation and upregulationTransforming growth factorImmunologyHypoxia-inducible factorsTransforming growth factor betaBiologyCancer researchTranscription factorChemistryCell biologyGeneBiochemistryGeneticsBacteriaOrganic chemistryOxygenOrthopedic Infections and TreatmentsInfective Endocarditis Diagnosis and ManagementInfectious Diseases and Tuberculosis