Peanut skin extract ameliorates the symptoms of type 2 diabetes mellitus in mice by alleviating inflammation and maintaining gut microbiota homeostasis
Lan Xiang, Qiaobei Wu, Hiroyuki Osada, Minoru Yoshida, Wensheng Pan, Jianhua Qi
Abstract
was remarkably reduced. PSE also increased the abundance of gut microbiota involved in fatty acid biosynthesis, lipid biosynthesis, and sucrose metabolism. The abundance of gut microbiota related to aminoacyl-tRNA biosynthesis also decreased. Lipopolysaccharide, interleukin (IL)-6, IL-1β and tumor necrosis factor-α in the blood, liver and adipose tissue were reduced by PSE. Similarly, the mRNA expression levels of IkappaB kinase and nuclear factor kappaB in the hypothalamus were reduced by PSE. These results suggested that PSE and MET elicited significant antidiabetic effects by maintaining gut microbiota and inhibiting inflammation.
Topics & Concepts
InflammationGut floraMedicineHomeostasisDiabetes mellitusType 2 Diabetes MellitusGlucose homeostasisImmunologyType 2 diabetesInternal medicineEndocrinologyInsulin resistanceGut microbiota and healthDiet and metabolism studiesTea Polyphenols and Effects