Microdialysis coupled with droplet microfluidics and mass spectrometry for determination of neurotransmitters <i>in vivo</i> with high temporal resolution
Shane S. Wells, Ian Bain, Alec C. Valenta, Ashley E. Lenhart, Daniel J. Steyer, Robert T. Kennedy
Abstract
Samples collected from brain of living subjects are segmented to nanoliter droplets and infused to the mass spectrometer. Temporal resolution for in vivo concentration dynamics of key neurotransmitters of 10 s is achieved. Created with Biorender.com.
Topics & Concepts
MicrodialysisMass spectrometryMicrofluidicsResolution (logic)In vivoHigh resolutionChromatographyChemistryMass spectrometry imagingNanotechnologyMaterials scienceBiologyComputer scienceArtificial intelligenceRemote sensingGeologyBiotechnologyInnovative Microfluidic and Catalytic Techniques InnovationMass Spectrometry Techniques and ApplicationsMicrofluidic and Capillary Electrophoresis Applications