Palladium-catalyzed carbonylative synthesis of 5-trifluoromethyl-1,2,4-triazoles from trifluoroacetimidohydrazides and aryl iodides
Jianhua Tang, Jiajun Zhang, Yu Zhang, Zhengkai Chen, Xiao‐Feng Wu
Abstract
A new palladium-catalyzed three-component carbonylative procedure for the construction of 5-trifluoromethyl-1,2,4-triazoles from trifluoroacetimidohydrazides and aryl iodides has been developed. TFBen is applied as a safe and convenient solid CO surrogate here.
Topics & Concepts
ChemistryTrifluoromethylPalladiumArylCatalysisCombinatorial chemistryOrganic chemistryAlkylFluorine in Organic ChemistrySynthesis and Biological EvaluationClick Chemistry and Applications