c-Kit signaling potentiates CAR T cell efficacy in solid tumors by CD28- and IL-2-independent co-stimulation
Yuquan Xiong, Meriem Taleb, Kyohei Misawa, Zhaohua Hou, Srijita Banerjee, Alfredo Amador-Molina, David R. Jones, Navin K. Chintala, Prasad S. Adusumilli
Topics & Concepts
Chimeric antigen receptorCD28Cancer researchT cellBiologyProgenitor cellTyrosine kinaseCell biologySignal transductionStem cellImmunologyImmune systemCAR-T cell therapy researchImmune Cell Function and InteractionImmunotherapy and Immune Responses