Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies
Bernard A. Fox, Walter J. Urba, Shawn M. Jensen, David B. Page, Brendan D. Curti, Rachel E. Sanborn, Rom S. Leidner
Abstract
The authors of a recent study identified noncanonical peptides (NCP) presented by cancer cells' HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers tested, providing opportunities for novel therapies to shared antigens. See related article by Lozano-Rabella et al., p. 2250.
Topics & Concepts
EpitopeAntigenCancerHuman leukocyte antigenCancer researchImmunologyBiologyGeneticsImmunotherapy and Immune Responsesvaccines and immunoinformatics approachesCancer Immunotherapy and Biomarkers