Enantioselective copper-catalysed defluorosilylation of trifluoro-methylated alkenes with silylboronates
Pan Gao, Liuzhou Gao, Longlong Xi, Zedong Zhang, Shuhua Li, Zhuangzhi Shi
Abstract
An efficient method for the construction of <italic>gem</italic>-difluoroallylsilanes with high enantiomeric excess <italic>via</italic> a copper-catalysed defluorosilylation of trifluoromethylated alkenes with silylboronates is described.
Topics & Concepts
ChemistryEnantioselective synthesisCopperEnantiomerEnantiomeric excessMedicinal chemistryOrganic chemistryCatalysisFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCarbon dioxide utilization in catalysis