Process intensification in continuous flow biocatalysis by up and downstream processing strategies
Lars‐Erik Meyer, Markus Hobisch, Selin Kara
Abstract
In this review, we focus on the holistic continuous enzymatic production and put special emphasis on process intensification by up- and downstream processing in continuous flow biocatalysis. After a brief introduction, we provide an overview of current examples of enzyme immobilization as an upstream process for flow biocatalysis. Thereafter, we provide an overview of unit operations as downstream processing strategies, namely continuous (i) liquid-liquid extraction, (ii) adsorptive downstream processing, and (iii) crystallization and precipitation. Eventually, we present our perspectives on future trends in this research field.
Topics & Concepts
Downstream processingDownstream (manufacturing)BiocatalysisBiochemical engineeringProcess (computing)Continuous flowFlow (mathematics)Process engineeringComputer scienceEnvironmental scienceChemistryEngineeringMechanicsCatalysisChromatographyBiochemistryOperations managementPhysicsIonic liquidOperating systemEnzyme Catalysis and ImmobilizationInnovative Microfluidic and Catalytic Techniques InnovationMicrobial Metabolic Engineering and Bioproduction