Kinetics of the mechanically induced ibuprofen–nicotinamide co-crystal formation by <i>in situ</i> X-ray diffraction
Lucia Casali, Maria Carta, Adam A. L. Michalchuk∞, Francesco Delogu, Franziska Emmerling
Abstract
powder X-ray diffraction data, coupled with analytical kinetic modelling, provides a powerful approach to gain mechanistic insight into mechanochemical reactions. By using the ibuprofen-nicotinamide co-crystal mechanosynthesis as a benchmark system, we investigate the behaviour of the solids involved and identify the factors that promote the reaction. As mechanochemical mechanisms become increasingly clear, it promises to become a breakthrough in the industrial preparation of advanced pharmaceuticals.
Topics & Concepts
MechanochemistryKineticsDiffractionIn situScalingMaterials scienceChemistryNicotinamideCrystallographyChemical engineeringNanotechnologyOrganic chemistryEngineeringPhysicsOpticsQuantum mechanicsMathematicsEnzymeGeometryCrystallography and molecular interactionsCrystallization and Solubility StudiesX-ray Diffraction in Crystallography