Toxic heavy metal concentrations in multiple sclerosis patients: a systematic review and meta-analysis
Sorour Sarihi, Maryam Niknam, Sanaz Mahjour, Mahnaz Hosseini‐Bensenjan, Fatemeh Moazzen, Sahar Soltanabadi, Hamed Akbari
Abstract
= 98.9 %, P <0.001), and Cd (WMD= 0.17 μg/L, 95 % CI= 0.09 to 0.26, P <0.001) were significantly higher in MS patients than those of the controls. However, there were no significant differences in the levels of Hg (WMD= -0.14 µg/L, 95 % CI= -0.77 to 0.49, P= 0.658) among both groups. Sensitivity analysis indicated that after excluding one-by-one study, the overall pooled WMD of Pb was changed. This meta-analysis showed that patients with MS had significantly higher levels of circulatory As and Cd compared to the controls. Yet, there was no statistically significant difference between circulating levels of Hg and Pb among MS patients and controls. See also Figure 1(Fig. 1).