Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor
L. Francisco Lorenzo‐Martín, Sonia Rodríguez‐Fdez, Salvatore Fabbiano, Antonio Abad, María Carmen García-Macías, Mercedes Dosil, Myriam Cuadrado, Javier Robles‐Valero, Xosé R. Bustelo
Topics & Concepts
BiologyGuanine nucleotide exchange factorIn vivoGuanosineCell biologyContext (archaeology)Cancer researchGTPaseBiochemistryGeneticsPaleontologyProtein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancerAdenosine and Purinergic Signaling