Ischemic-hypoxic preconditioning enhances the mitochondrial function recovery of transplanted olfactory mucosa mesenchymal stem cells via miR-181a signaling in ischemic stroke
Yi Zhuo, Wei Chen, Wenshui Li, Yan Huang, Da Duan, Lite Ge, Jialin He, Jianyang Liu, Zhiping Hu, Ming Lü
Abstract
. Ischemic-hypoxic preconditioned OM-MSCs (IhOM-MSCs) were used to treat a neuron model of oxygen-glucose deprivation/reperfusion and the middle cerebral artery occlusion in rats. These results demonstrated that IhOM-MSCs mediated the upregulation of the downstream target genes GRP78 and Bcl-2 by miR-181a to protect mitochondrial function and inhibit apoptosis and pyroptosis of neurons in the ischemia/reperfusion injury model. Thus, IhOM-MSCs transplantation may be an effective therapy of ischemic stroke in the future.
Topics & Concepts
Mesenchymal stem cellIschemic strokeOlfactory mucosaCell biologyMitochondrionMedicineIschemiaNeuroscienceBiologyOlfactory systemCardiologyNeurological Disease Mechanisms and TreatmentsMesenchymal stem cell researchNeuroinflammation and Neurodegeneration Mechanisms