Population Pharmacokinetics of Piperacillin following Continuous Infusion in Critically Ill Patients and Impact of Renal Function on Target Attainment
Vibeke Klastrup, Anders Thorsted, Merete Storgaard, Steffen Christensen, Lena E. Friberg, Kristina Öbrink‐Hansen
Abstract
Pharmacokinetic changes are often seen in patients with severe infections. Administration by continuous infusion has been suggested to optimize antibiotic exposure and pharmacokinetic/pharmacodynamic (PK/PD) target attainment for β-lactams. In an observational study, unbound piperacillin concentrations ( n = 196) were assessed in 78 critically ill patients following continuous infusion of piperacillin-tazobactam (ratio 8:1). The initial dose of 8, 12, or 16 g (piperacillin component) was determined by individual creatinine clearance (CRCL).
Topics & Concepts
PharmacokineticsPiperacillinRenal functionCritically illMedicineIntensive care medicineMetabolic clearance ratePopulationPopulation pharmacokineticsPiperacillin/tazobactamPharmacologyInternal medicineBiologyEnvironmental healthPseudomonas aeruginosaBacteriaGeneticsAntibiotics Pharmacokinetics and EfficacyPneumonia and Respiratory InfectionsAntibiotic Resistance in Bacteria