Organocatalytic regio-, diastereo- and enantioselective γ-additions of isoxazol-5(4<i>H</i>)-ones to β,γ-alkynyl-α-imino esters for the synthesis of axially chiral tetrasubstituted α-amino allenoates
Fushuai Li, Shuai Liang, Yepeng Luan, Xuling Chen, Hanhui Zhao, Anqi Huang, Pengfei Li, Wenjun Li
Abstract
The chiral phosphoric acid catalyzed regio-, diastereo- and enantioselective reaction of isoxazol-5(4<italic>H</italic>)-ones with β,γ-alkynyl-α-imino esters has been developed.
Topics & Concepts
Enantioselective synthesisChemistryPhosphoric acidCatalysisOrganic chemistryStereochemistryCombinatorial chemistryAsymmetric Synthesis and CatalysisAxial and Atropisomeric Chirality SynthesisCyclopropane Reaction Mechanisms