Hydrogenation of Carboxylic Esters Catalyzed by Phosphine-Free Bis-N-heterocyclic Carbene Manganese Complexes
Karim Azouzi, Lucie Pedussaut, Romane Pointis, Anna Bonfiglio, Riddhi Kumari Riddhi, Carine Duhayon, Stéphanie Bastin, Jean‐Baptiste Sortais
Abstract
As an earth-abundant transition metal, manganese is now recognized as a good candidate for the development of catalysts for reduction-type reactions. It is often associated with a noninnocent tridentate ligand, featuring an acidic NH moiety. We report here that a simple bidentate and phosphine-free bis-N-heterocyclic ligand associated with manganese in the complex [Mn(bis-NHC Mes )(CO) 3 Br] could catalyze the hydrogenation of carboxylic esters in the presence of KBHEt 3 as an activator at 100–120 °C under 50 bar of H 2 at 1 mol % catalyst loading in 2-Me-THF.
Topics & Concepts
ChemistryDenticityManganeseCarbenePhosphineCatalysisLigand (biochemistry)MoietyMedicinal chemistryTransition metalMetalOrganic chemistryReceptorBiochemistryAsymmetric Hydrogenation and CatalysisCarbon dioxide utilization in catalysisN-Heterocyclic Carbenes in Organic and Inorganic Chemistry