Facile Synthesis of Chiral Arylamines, Alkylamines and Amides by Enantioselective NiH‐Catalyzed Hydroamination
Lingpu Meng, Jingjie Yang, Mei Duan, You Wang, Shaolin Zhu
Abstract
Regio- and enantioselective hydroarylamination, hydroalkylamination and hydroamidation of styrenes have been developed by NiH catalysis with a simple bioxazoline ligand under mild conditions. A wide range of enantioenriched benzylic arylamines, alkylamines and amides can be easily accessed by nitroarenes, hydroxylamines and dioxazolones, respectively as amination reagents. The chiral induction in these reactions is proposed to proceed through an enantiodifferentiating syn-hydronickellation step.
Topics & Concepts
Enantioselective synthesisHydroaminationAminationCatalysisChemistryReagentLigand (biochemistry)Combinatorial chemistryChiral ligandAsymmetric inductionOrganic chemistryBiochemistryReceptorCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions