Remarkably Enhanced Luminol/H<sub>2</sub>O<sub>2</sub> Chemiluminescence with Excellent Peroxidase-like Activity of FeCoNi-based Metal-Organic Xerogels for the Sensitive Detection of Dopamine
Fangshuo Liu, Shiyu Xia, Ala’a Mhmoued Abdllh Alboull, Zhiyong Dong, Hongzhan Liu, Chengda Meng, Fengxia Wu, Guobao Xu
Abstract
Metal-organic gels (MOGs) are a category of metal-organic smart soft materials with large specific surface areas, loose porous structures, and open metal active sites. In this work, trimetallic Fe(III)Co(II)Ni(II)-based MOGs (FeCoNi-MOGs) were synthesized at room temperature via a simple and mild one-step procedure. Fe 3+, Co 2+, and Ni 2+ were the three central metal ions in it, while 1,3,5-benzenetricarboxylic acid (H 3 BTC) served as the ligand. The solvent enclosed in it was then removed by freeze-drying to get the corresponding metal-organic xerogels (MOXs). The as-prepared FeCoNi-MOXs have excellent peroxidase-like activity and can significantly enhance luminol/H 2 O 2 chemiluminescence (CL) by more than 3000 times, which is very effective compared with other reported MOXs. Based on the inhibitory effect of dopamine on the CL of the FeCoNi-MOXs/luminol/H 2 O 2 system, a simple, rapid, sensitive, and selective CL method for dopamine detection was established with a linear range of 5–1000 nM and a limit of detection of 2.9 nM (LOD, S/N = 3). Furthermore, it has been effectively used for the quantitative measurement of dopamine in dopamine injections and human serum samples, with a recovery rate of 99.5–109.1%. This research brings up prospects for the application of MOXs with peroxidase-like activity in CL.